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Retatrutide (AP3-R)

AP3-R vs AP2-T vs AP1-S: Choosing Between Triple, Dual, and Single Agonists

2026-06-03 · 5 min read

Most metabolic research programs end up stocking more than one incretin reference compound. The three we ship most are AP3-R, AP2-T, and AP1-S, and the choice between them is usually about receptor coverage rather than price.

Receptor coverage

AP1-S (semaglutide) is a single GLP-1 receptor agonist. AP2-T (tirzepatide) adds GIP receptor activity from a GIP-based backbone. AP3-R (retatrutide) adds glucagon receptor engagement on top of both, which is why it appears in hepatic lipid and energy-expenditure designs where the other two are insufficient.

Cost per vial at wholesale

At 10 mg fills, AP1-S lists at $21, AP2-T at $22, and AP3-R at $23 per vial — close enough that comparator studies rarely get priced out. Kits are ten vials, and the same volume ladder applies to all three, so a lab stocking one kit of each still qualifies for the three-kit tier.

Practical stocking advice

Groups running comparator work usually keep one kit of each on hand and reorder the single compound their protocol consumes fastest. Because the minimum is one kit, that pattern costs no more than buying a single SKU in bulk.

Ordering, minimums, and pricing

Every SKU is priced per vial and sold in sealed ten-vial kits with a one-kit minimum. Volume tiers: 1 kit at list, 2 kits at 5% off, 3 kits at 7% off, 5 kits at 12% off, and 10 kits at 20% off. Domestic orders received by 2PM PT dispatch the same business day, and freight is free above $2,500.

All compounds are sold as chemical reagents for laboratory research use only — not for human or veterinary use.

Frequently asked

What is the minimum order?
One ten-vial kit of any in-stock SKU. Mix compounds freely to reach a volume tier.
Do orders include a certificate of analysis?
Yes — lot-specific, with third-party HPLC purity and mass-spec identity.
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